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Projects beginning in 2006

An investigation into geno-type phenotype relationships using gene variants known to alter traits related to type 2 diabetes

Aims

To analyse common variants that reproducibly alter fasting glucose, triglycerides, HDL or type 2 diabetes risk.

Investigators

Project status

In progress

Predictors of the development of cancer in the 1981 Busselton cohort

Aims

1. To determine if a high white cell count predicts onset of cancer
2. To determine whether left-handedness increases the risk of breast cancer

Investigators

Project status

In progress

Publications

Fritschi L, Divitini M, Talbot-Smith A, Knuiman M.  Left-handedness and risk of breast cancer. British Journal of Cancer 2007; 97: 686-687. Abstract.

The prevalence of sleep apnoea and sleep apnoea symptoms in Busselton

Aims

To conduct a new cross-sectional survey of a random sample from the Busselton population and use these data together with longitudinal data to:

  1. determine the current prevalence of sleep apnoea and sleep disordered symptoms in a normal Australian adults population
  2. estimate the effects of sleep apnoea on asthma and COPD
  3. investigate relationships between sleep disorders and other conditions

Investigators

  • Clin Assoc Prof Alan James, WA Sleep Disorders Research Institute, SCGH
  • Dr Stewart Cullen, WA Sleep Disorders Research Institute, SCGH
  • Prof Matthew Knuiman, School of Population Health, UWA
  • Prof Lyle Palmer, WAIMR
  • Dr Sutapa Mukherjee, WA Sleep Disorders Research Institute, SCGH

Project status

In progress

Validation of genetic associations in asthma and allergy in Canadian and Australian families

Aims

To test if common susceptibility gene variants are associated with asthma and allergy in two well phenotyped collections of cases.

Investigators

  • Clin Assoc Prof Alan James, Department of Pulmonary Physiology, SCGH
  • Clin Prof Bill Musk, Department of Respiratory Medicine, SCGH
  • Dr John Beilby, Department of Clinical biochemistry, Pathwest
  • Prof Lyle Palmer, WAIMR
  • Dr Thomas Hudson, McGill University
  • Prof Peter Pare, University of British Columbia

Project status

Completed

Estimates of mortality attributable to obesity and regression dilution

Aims

To assess whether regression-dilution effects can help explain the present uncertainty about the level of mortality attributable to obesity.

Investigators

  • Dr James Greenberg, University of New York

Project status

Seeking funding (not yet commenced)                               

Analysing the familial and environmental factors of asthma using visualisation and statistical techniques

Aims

To develop novel techniques to visualise pedigrees on a population scale, and test these techniques using the Busselton Health Study data.

Investigators

  • Dr Angeline Loh, WAIMR
  • Dr Kim Carter, WAIMR
  • Prof Lyle Palmer, WAIMR

Project status

Terminated

Thyroid function and autoimmunity in the Busselton Health Study: a longitudinal community-based study

Aims

To study baseline serum levels of thyroid hormones in relation to development of hypothyroidism

Investigators

  • Prof John Walsh, Department of Endocrinology and Diabetes, SCGH
  • Prof Peter Leedman, Department of Medicine and Pharmacology, UWA
  • Dr Peter O’Leary, Department of Health, WA Government
  • Dr Alexandra Bremner, School of Population Health, UWA

Project status

In progress

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This page was last modified by G Maier on 2008-04-29